About the Project
An additional issue with currently used wound dressings is that they tend to be inflexible in nature and cover the wound surface without packing into contoured wounds, therefore, bacteria can inevitably escape. Wound dressing removal and re-application can also be painful for the patient and, in these cases, the use of biodegradable membranes which would degrade within the infected wound would be of great benefit.
An ideal wound dressing would therefore be multifunctional and contain a non-antibiotic antibacterial mechanism and an anti-inflammatory/pain relieving agent. It should also be flexible enough to pack into contoured wounds and biodegradable.
The aim of this project is to create a new bi-layered construct to be used as a wound dressing in the treatment of chronic infected wounds. This construct will be flexible and biodegradable and it will be manufactured using FDA approved polymers and electrospinning. The bi-layered scaffold will be multifunctional: (i) Layer 1 will include an anti-inflammatory agent; (ii) Layer 2 will include an antibacterial component (cerium derivative).The student undertaking this project will be expected to develop and characterise the bi-layered scaffold and then test its antibacterial activity using clinically relevant bacterial species (e.g. Pseudomonsa aeruginosa and Staphylococcus aureus) both in 2D models and in 3D tissue engineered models of skin wound infection. The project will be developed in a multidisciplinary environment working at The School of Dentistry with Dr. Ilida Ortega (expert in Biomaterials) and Dr. Joey Shepherd (expert in Microbiology).
This project is open to self-funded students only.
Candidates must have a first or upper second class honors degree or significant research experience.
Interested candidates should in the first instance contact Dr. Ilida Ortega Asencio ([Email Address Removed])
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply
Please clearly state the prospective main supervisor in the respective box and select 'School of Clinical Dentistry' as the department.
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.
Biodegradable composite materials (Bio-PolyMOFs) for applications in targeted delivery of drugs to improve healthcare and reduce antimicrobial resistance in developing countries and worldwide
University of Bradford