Developing immunised PDX models for prostate cancer

Prostate cancer (PCa) is the most commonly diagnosed cancer in men in Western countries and the third leading cause of cancer-related deaths. Animal models that better recapitulate this human disease and retain the molecular and cellular characteristics of patient tumours are urgently needed. This study aims to develop patient derived xenograft models for prostate cancer with a partially intact human immune system. This will allow us to study the impact of cancer immunotherapies in combination with conventional treatments on immunity. The project will establish a bank of human patient derived cell lines that grow in mice and can be used to study the influence of drug treatment combinations both in vitro and in vivo.

Entry Requirements:

Candidates must have a first or upper second class honors degree or significant research experience.

How to apply:

Please complete a University Postgraduate Research Application form available here: https://www.sheffield.ac.uk/postgraduate/phd/apply/applying

Please clearly state the prospective main supervisor in the respective box and select Oncology and Metabolism as the department.

Proposed start date - October 2021