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Developing multi-modal functional MRI approaches for clinical use

Project Description

We aim to develop multi-modal functional MRI to use in patients with lung disease. Hyperpolarised xenon-129 MRI (129Xe-MRI) is our focus.

129Xe-MR lung imaging has been in development for over two decades and 129Xe-MR brain imaging is an emerging field. The successful applicant will be responsible for developing ADC and dissolved phase imaging capabilities at University of Nottingham for both pulmonary and neuro-imaging, on multiple MRI platforms, with particular focus on the open upright 0.5T MRI scanner. They will also develop under-sampling methods, such as compressed sensing sequences coupled with deep learning, to maximally exploit the magnetisation of the hyperpolarised noble gas.

The student will be working with physicists and clinicians, and involved in clinical studies. The potential clinical studies are:

1- impact of cystic fibrosis transmembrane conductance regulator (CFTR) potentiators in patients with cystic fibrosis
2- cognitive impairment in patients with chronic (e.g. emphysema) and acute respiratory disease (e.g. pneumonia)

The student will be supported by clinical academics and MR physicists at the Nottingham NIHR Biomedical Research Centre and the Sir Peter Mansfield Imaging Centre.

Funding Notes

Deadline for applications is 25 February 2019, with interviews for applicants to take place between 4 and 8 March 2019
Applicants for the Precision Imaging PhD programme should have at least a 2:1 degree, or equivalent, in a project-relevant discipline. Funding is only available for UK and EU students.

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