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Developing new antimicrobials

  • Full or part time
  • Application Deadline
    Friday, January 31, 2020
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Antibiotic resistance is documented by the World Health Organisation as one of the three most important threats to human health. European Centre for Disease Prevention and Control (ECDC) and the European Medicines Agency (EMEA) found that more than 700 000 people globally die every year as a result of antibiotic resistance. By 2050, this figure could reach over 10 million, which is more than the current number of annual cancer death. To keep pace with the spread of antimicrobial resistance we need to look for alternative antimicrobial therapeutics.
The present study aims to develop novel antimicrobial therapeutics based on antimicrobial peptides (AMPs). AMPs show activity towards a broad range of microorganisms, including some antibiotic-resistant bacterial strains, fungi, viruses and parasites. In addition, AMPs can modulate the immune system, thereby helping the eradication of a pathogen. This project will combine newly developed synthetic biology and biocatalysis approaches with AMP synthesis to address the global challenge of antibiotic resistance.

Funding Notes

Stipend of €18,000/year (plus tuition fees) for 4 years
Candidates for this position should have a MSc degree or BSc degree (minimum 2:1 honours, or equivalent) in Microbiology, Biology or related discipline. Candidates should have a strong aptitude for computational analysis. It is desirable that candidates have experience in bacterial engineering and bioinformatics.

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