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Developing new treatments by targeting RNA splicingcontrol in squamous cell carcinoma.


Department of Pathology

About the Project

Despite extensive work to understand squamous cell carcinoma biology there are few targeted therapies in this disease. Transcriptional programs are consistently disregulated in SCC across organ types and RNA splicing is consistently disrupted in cancers, particularly SCCs. There are extensive splicing changes in the shift from normal epithelium to SCC. We found splicing alterations implicated in the shift from
normal to malignant epithelium in patientderived RNA sequencing data which is recapitulated in cell line models. We will deploy sophisticated computational RNA modeling to identify specific targets in the splicing machinery which underpin SCC development and develop therapeutic molecules against them.

Funding Notes

Funding* will cover the student’s stipend at the current Research Council rate and University Fees. The studentship will be funded for three years in the first instance subject to eligibility, with the possibility of additional funding in the fourth year depending on circumstances.

*The studentships are available to students who qualify for Home fees

Applications from ineligible candidates will not be considered.

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References

Vitsios DM, Davis MP, van Dongen S, Enright AJ. Large-scale
analysis of microRNA expression, epi-transcriptomic features and
biogenesis. Nucleic Acids Res. 2017 Feb 17;45(3):1079-1090
P Maziere, AJ Enright . Prediction of microRNA targets. Drug
discovery today. 2007. 12 (11-12): 452-458
S Van Dongen, C Abreu-Goodger, AJ Enright . Detecting
microRNA binding and siRNA off-target effects from expression
data. Nature methods, 2008. 5 (12) 1023-1025

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