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Developing novel drug delivery approaches to treat ocular disorders

  • Full or part time
    Prof V Khutoryanskiy
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Ocular diseases affect the quality of life of millions of people worldwide. The leading causes of chronic blindness include cataract, glaucoma, age-related macular degeneration, corneal opacities, diabetic retinopathy, and trachoma. Many of the most important eye diseases, in terms of both their incidence and potential to cause blindness, are age-related.

Despite the easy accessibility of the eye for drug administration, ophthalmic delivery is a very challenging area of pharmaceutics because of several ocular barriers, including blinking, the tear reflex, nasolacrymal drainage and poor corneal permeability. This project will be focusing on the development of advanced drug delivery systems for ocular therapeutics. Ocular drug bioavailability can be enhanced either by prolonging the retention of a formulation on the surface of the eye or by facilitating transcorneal penetration. The project will include (1) design of novel drug delivery systems and their physicochemical characterisation; (2) in vitro studies of precorneal retention of ocular dosage forms and penetration of drugs through ocular membranes; (3) toxicological assessment of novel drug delivery systems; and (4) in vivo evaluation of systems developed.

You will join successful multidisciplinary group of researchers, providing lots of training and career opportunities. See our web site https://www.reading.ac.uk/pharmacy/about/staff/v-khutoryanskiy.aspx and follow us on Twitter: https://twitter.com/vk_group_rsop
Our recent publications in this area:

1. Mun E.A., Morrison P.W.J., Williams A.C., Khutoryanskiy V.V. On the barrier properties of the cornea: A microscopy study of the penetration of fluorescently labelled nanoparticles, polymers, and sodium fluorescein, Mol. Pharm., 11, 3556-3564 (2014), http://pubs.acs.org/doi/abs/10.1021/mp500332m

2. Morrison P.W. and Khutoryanskiy V.V. Enhancement in Corneal Permeability of Riboflavin Using Calcium Sequestering Compounds, Int. J. Pharm., 472, 56-64 (2014), http://www.sciencedirect.com/science/article/pii/S037851731400427X

3. Morrison P.W.J., Khutoryanskiy V.V. Advances in Ophthalmic Drug Delivery, Therapeutic Delivery, 5 (12), 1307–1325 (2014), http://www.future-science.com/doi/abs/10.4155/tde.14.75






Funding Notes

We welcome applications from self-funded students worldwide for this project.
Eligibility:

• Applicants should hold or expect to gain a minimum of a 2:1 Bachelors Degree in pharmacy, materials science, chemistry, biomedical engineering or a related discipline.

How good is research at University of Reading in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 23.20

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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