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Developing novel formulations and materials for transmucosal drug delivery

  • Full or part time
    Prof V Khutoryanskiy
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Mucosal routes of drug administration offer numerous advantages including ease of application, non-invasive nature and sometimes possibility of targeting particular organs. We are interested in the development of novel dosage forms and materials for transmucosal routes of drug delivery. Areas of interest include drug delivery to the eye, nose, oral cavity, gastrointestinal tract, urinary bladder, vagina and rectum. In a typical project we look at the use of chemical modification of existing pharmaceutical polymers to enhance their properties and we design new polymeric materials in the form of soluble polymers, nano- and microparticles, hydrogels, in situ gelling systems or simple tablets. The project may involve the use of different instrumental techniques including different spectroscopies, thermal analysis, chromatographic techniques, mechanical and texture analysis, electron and fluorescent microscopy and work with freshly excised animal mucosal tissues.
You will join successful multidisciplinary group of researchers, providing lots of training and career opportunities. See our web site https://www.reading.ac.uk/pharmacy/about/staff/v-khutoryanskiy.aspx and follow us on Twitter: https://twitter.com/vk_group_rsop
Our recent publications in this area:

1. Mun E.A., Morrison P.W.J., Williams A.C., Khutoryanskiy V.V. On the barrier properties of the cornea: A microscopy study of the penetration of fluorescently labelled nanoparticles, polymers, and sodium fluorescein, Mol. Pharm., 11, 3556-3564 (2014), http://pubs.acs.org/doi/abs/10.1021/mp500332m

2. Morrison P.W. and Khutoryanskiy V.V. Enhancement in Corneal Permeability of Riboflavin Using Calcium Sequestering Compounds, Int. J. Pharm., 472, 56-64 (2014), http://www.sciencedirect.com/science/article/pii/S037851731400427X

3. Morrison P.W.J., Khutoryanskiy V.V. Advances in Ophthalmic Drug Delivery, Therapeutic Delivery, 5 (12), 1307–1325 (2014), http://www.future-science.com/doi/abs/10.4155/tde.14.75






Funding Notes

We welcome applications from self-funded students worldwide for this project.

Eligibility:
Applicants should hold (or expect to gain) a minimum of a 2:1 undergraduate degree (or equivalent) in chemistry, biochemistry, biomedical sciences, pharmacology, or related disciplines.

References

Recent publications in this area include:
1. Moustafine R.I., Victorova A.S., Khutoryanskiy V.V. Interpolymer complexes of Carbopol® 971 and poly(2-ethyl-2-oxazoline): physicochemical studies of complexation and formulations for oral drug delivery, Int. J. Pharm., 558, 53–62 (2019)
2. Ways T.M.M., Lau W.M., Ng K.W., Khutoryanskiy V.V. Synthesis of thiolated, PEGylated and POZylated silica nanoparticles and evaluation of their retention on rat intestinal mucosa in vitro, Eur. J. Pharm. Sci., 122, 230-238 (2018)
3. Kaldybekov D.B., Tonglairoum P., Opanasopit P., Khutoryanskiy V.V. Mucoadhesive maleimide-functionalised liposomes for drug delivery to urinary bladder, Eur. J. Pharm. Sci., 111, 83-90 (2018)
4. Morrison P.W.J., Porfiryeva N.N., Chahal S., Salakhov I.A., Lacourt C., Semina I.I., Moustafine R.I., Khutoryanskiy V.V.* Crown Ethers: novel permeability enhancers for ocular drug delivery? Mol. Pharm., 14, 3528–3538 (2017)

How good is research at University of Reading in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 23.20

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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