Developing novel glycan-functionalised composite biomaterials for improving bone formation


   School of Chemical Engineering

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  Prof Simon Cool, Dr Alex Smith  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

Heparan sulphate (HS) plays key roles in many biological processes, including wound healing, as it binds and protects critical pro-regenerative factors within a wound site. HS-functionalised biomaterials have shown promise in enhancing the endogenous wound healing response in various models, including bone repair.

This project aims to investigate novel methods for functionalising common biomaterials used in bone repair (such as (poly)caprolactone and hydroxyapatite) with HS using several different grafting strategies. These novel, glycan-functionalised biomaterials will then be characterised extensively using chemical, physical, biophysical, and biological techniques to assess structure, function, and ability to enhance osteogenesis.

Biological Sciences (4) Engineering (12) Medicine (26)

References

Minimum structural requirements for BMP-2-binding of heparin oligosaccharides
Smith, Raymond A.A., Murali, Sadasivam, Rai, Bina, Lu, Xiaohua, Lim, Zophia Xue Hui, Lee, Jaslyn J.L., Nurcombe, Victor and Cool, Simon M. (2018). Minimum structural requirements for BMP-2-binding of heparin oligosaccharides. Biomaterials, 184, 41-55. doi: 10.1016/j.biomaterials.2018.08.056
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