Developing novel radiolabeled nanoparticles for tracking delivery of therapeutic readionuclides and chemotherapeutics to hard-to-treat cancers
The EPSRC Centre for Doctoral Training in Sensor Technologies and Applications, in collaboration with Hitachi, is inviting applications for a fully funded 1+3 years MRes + PhD studentship, commencing in October 2019. The studentship will be hosted in the BioNanoEngineering group (https://www.fruk-lab.com) in the Department of Chemical Engineering and Biotechnology, but will be shared with Department of Radiology, University of Cambridge. The Studentship aims at developing novel radiolabeled nanoparticles for tracking delivery of therapeutic readionuclides and chemotherapeutics to hard-to-treat cancers. This is inspired by recent developments in nanocarrier design, which provided an opportunity to improve the delivery and efficiency of therapeutics for cancer treatment. However, despite the developments, only few nanotechnology inspired formulations made it to the market due to the lack of control over mechanical and physiochemical properties of carriers, limited biological barrier penetration and limited data on their post-drug delivery fate. We want to combine radiolabels, biocompatible nanocarrier and therapeutic cargo to prepare multifunctional nanoparticle system for targeting lung and pancreatic cancer. This work will be performed across the Departments of Chemical Engineering and Biotechnology, Radiology and Oncology, and it will involve use of chemical approaches to nanocarrier design, validation of nanocarriers in in-vivo systems and PET imaging.
The project can be driven in several directions and will appeal to students with either a strong background in chemical synthesis, biochemistry, pharmacy or medicine. The studentship is fully-funded for 4-years and will be hosted at the University of Cambridge in the Department of Chemical Engineering and Biotechnology. The student will be enrolled in the Centre for Doctoral Training in Sensor Technologies and Applications (http://cdt.sensors.cam.ac.uk). The first year involves a highly interdisciplinary programme consisting of lectures, practicals, and research projects covering a wide range of technologies and applications in sensing and imaging. Successful completion of the first year will lead to a Master of Research qualification (MRes) and optimal preparation for the PhD project in years 2-4. The project will be carried out in collaboration with Hitachi and internships at Hitachi are a possibility for those interested. We are seeking a highly motivated PhD student with a strong academic background, as demonstrated with a 1st or upper 2nd class degree, or equivalent, in a relevant discipline. The candidate will have a demonstrable interest in drug formulation and drug delivery and have a gasp of chemical strategies.
Fixed-term: The funds for this post are available for 4 years in the first instance.
For informal enquiries please contact Dr Ljiljana Fruk ([Email Address Removed]) To apply for this position please visit http://cdt.sensors.cam.ac.uk/how-to-apply The deadline for applications is 7 June 2019. Note that full funding (fees and stipends) is available for EU / EEA / Swiss citizens or applicants who have been resident in the UK for the last 3 years. For eligibility enquiries, please contact [Email Address Removed].
Please quote reference NQ19148 on your application and in any correspondence about this vacancy.
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