About the Project
This is an exciting time for the wider field of ocular gene therapy with numerous clinical trials ongoing and one clinically approved that may be offered by NHS as of January 2020. This project offers a fantastic opportunity to answer important questions and move the optogenetic gene therapies closer to successful clinical application. The student will receive expert training in highly sought-after techniques (gene delivery, in vivo and surgical techniques (including the use of large scale in vivo and in vitro electrophysiological recording), molecular biology techniques (including optogenetics and viral vector design)), and live-cell reporter assays and tissue culture and have excellent preparation for future work in biomedical research and regenerative medicine.
The successful applicant join a dynamic and multidisciplinary group spanning molecular biology, systems physiology and computational approaches. The supervisory team have an outstanding track record in research excellence and have an active and successful program developing innovative optogenetic therapies for retinal degeneration.
Techniques/training to be provided:
The student will gain a strong grounding in numerous key biomedical techniques including: viral gene delivery; in vivo and surgical techniques (including the use of large scale in vivo and in vitro electrophysiological recording);molecular biology techniques (including optogenetics and viral vector design.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in in vivo experiments or with an interest in electrophysiology are encouraged to apply.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Storchi R, Bedford RA, Martial FP, Allen AE., Wynne J, Montemurro MA, Petersen RS, Lucas RJ. (2017) Modulation of fast narrowband oscillations in the mouse retina and dLGN according to background light intensity. Neuron 93(2):299-307
Ballister ER, Rodgers J, Martial F, Lucas RJ (2018) A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling. BMC Biology 16(1):10
Milosavljevic N, Storchi R, Eleftheriou CG, Colins A, Petersen RS, Lucas RJ. Photoreceptive retinal ganglion cells control the information rate of the optic nerve. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11817-E11826
Gerrard E, Mutt E, Nagata T, Koyanagi M, Flock T, Lesca E, Schertler GFX, Terakita A, Deupi X, Lucas RJ. (2018) Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish. Proc Natl Acad Sci U S A 115(24):6201-6206
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.