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Development and evaluation of small Inhibitors of HUWE1 for the treatment of Multiple Myeloma

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  • Full or part time
    Dr L Crawford
    Dr R Williams
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

HUWE1 is a large HECT-domain E3 ligase that is involved in the regulation of key proteins such as p53, MYC and MCL-1. We have identified elevated expression of HUWE1 in Multiple Myeloma (MM) and demonstrate that knockdown of this ligase leads to growth arrest of MM cell lines both in vitro and in vivo. Dysregulation of HUWE1 is also reported in numerous other tumour types, making it an attractive therapeutic target.

Two small molecule inhibitors of HUWE1 have previously been identified through high-throughput screening, however, their therapeutic potential is limited due to unfavourable therapeutic properties. Under the guise of this PhD studentship, we aim to further develop these inhibitors and evaluate their activity using a variety of biological activities.

This is an interdisciplinary project involving both chemistry and molecular biology techniques that would be ideally suited to candidates with a background in molecular biology, biochemistry or pharmaceutical sciences.

ENTRY REQUIREMENTS

Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject.

English Language

Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.

The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
• A valid Certificate of Proficiency in English grade A or B;
• A valid Certificate of Advanced English grade A; or
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.

For a list of English Language qualifications also accepted by the School and University please see the following link:
http://www.qub.ac.uk/International/International-students/Applying/English-language-requirements/#English

INTO Queen’s English Language Courses offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained at: https://www.qub.ac.uk/International/International-students/Applying/University-Preparation-Courses/INTOEnglishlanguagecoursesatQueens/

Funding Notes

*FUNDING CONFIRMED – Leukaemia and Lymphoma NI Studentship*

Eligibility for both fees (£4,327 for 2019/20, 2020/21 TBC) and maintenance (£15,009 for 2019/20, 2020/21 TBC) depends on the applicants being either an ordinary UK or EU resident.

References

Please visit the School of Medicine, Dentistry and Biomedical Sciences, Centre for Cancer Research and Cell Biology, website for further details about the Centre:

http://www.qub.ac.uk/research-centres/CentreforCancerResearchCellBiology/

When applying, please choose 'MEDICINE' as your subject area/School.



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