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Development and validation of novel MRI methods using preclinical models of disease.

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Project Description

At Glasgow’s Experimental MRI Centre we are interested in pushing the boundaries of Magnetic Resonance Imaging (MRI) and its application to biomedical research. We are developing and investigating several novel MRI methods, including diffusion weight arterial spin labeling, advanced velocity imaging, diffusion and metabolic imaging using O17. These methods are then used to investigate a range of preclinical disease models, which include cardiovascular disease, kidney disease, cancer and stroke. Projects will have a secondary supervisor who is an expert in the particular disease model, giving the PhD student the chance to gain experience both within world-leading biomedical research groups, as well as in magnetic resonance imaging. The MRI center currently houses two 7Tesla MRI systems in a purpose designed building, which also contains surgical theatres, animal holding rooms and physics workshop.

Benefits and Training
• Learn both MRI physics and its application
• Strong benefit from established collaborations, providing opportunity to work with multidisciplinary teams of clinicians, physicists and biomedical scientists.
• Opportunity to participate and present at international conferences, attend summer schools and workshops on new developments in MRI and MRI processing techniques.
• Freedom to develop new skills via our graduate school courses and access to relevant undergraduate courses.

References

1. A. Vallatos, H.F.I. Al-Mubarak, J. L. Birch, L. Galllagher, J. M. Mullin, L. Gilmour, W.M. Holmes† and A.J. Chalmers† .Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region," Journal of Magnetic Resonance Imaging.2018. In PRESS.

2. Vallatos A, Gilmor L, Chalmers A and Holmes WM. Multiple boli Arterial Spin Labelling for high signal-to-noise rodent brain imaging. Magnetic Resonance in Medicine. 2017. 79. 1020-1030.

3. Merrifield GD, Mullin J, Gallagher L, Tucker C, Jansen MA, Denvir M, Holmes WM. Rapid and recoverable in vivo MRI of adult zebrafish at 7T. Magnetic Resonance Imaging. 2017; 37:9-15.

4. Vallatos A, Al Mubarak H, Mullin J, and Holmes WM. (2018) Accuracy of phase-contrast velocimetry in systems with skewed intravoxel velocity distributions. Journal of Magnetic Resonance. 2018; 296: 121-129.


5. Holmes WM, Lopez-Gonzalez MR, Gallagher L, Deuchar GA, Macrae IM, Santosh C. Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity. NMR in Biomedicine. 2012. 25: 295-304.

6. Baskerville TA, McCabe C, Mullin J, Carberry L, Macrae IM, Holmes WM. Non-invasive MRI measurement of CBF: validating an arterial spin labelling sequence with 99mTc-HMPAO CBF autoradiography in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism. 2012. 32: 973-977.

7. Pawlikowski, J.S. et al. (2015) Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling. Journal of Investigative Dermatology, 135(8), pp. 2093-2101.

How good is research at University of Glasgow in Clinical Medicine?

FTE Category A staff submitted: 177.40

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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