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Development of a 3D Printed Biohybrid Lung (SAM27)

Project Description

Loughborough University is a top-ten rated university in England for research intensity (REF2014). In choosing Loughborough for your research, you’ll work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career.

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Project detail

This exiting and highly multidisciplinary and interpectoral project will develop and optimise the bio-hybridisation of the blood contacting surfaces of a 3D-printed oxygenator with seeded endothelial cells (ECs), with a view to developing a longer-lasting bridge to lung transplantation or a destination therapy. Although lung transplantation remains the only curative therapy for patients with end-stage lung (ELD) disease, the low donor availability and patient ineligibility limit the number of transplantations, with the need significantly outnumbering supply. Extracorporeal membrane oxygenation (ECMO) represents the only viable alternative to lung transplantation, but the high frequency of thrombotic events and imperfect haemodynamics render current ECMO technologies suitable only for short-term application.

The project will develop a clinically-relevant technology that will be readily translatable through our clinical collaborators and will dramatically benefit the quality of life of ELD patients. In addition, this project offers an excellent opportunity for developing highly interdisciplinary skills at the engineering-life sciences interface, while working in the world-leading Centre for Biological Engineering at Loughborough University, greatly enhancing the prospects for a future career in academia or the medical devices industrial sector.

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Start date of studentship: 01 October 2020.

Entry requirements

Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in biological sciences or biotechnology or a related subject. A relevant Master’s degree and/or experience in one or more of the following will be an advantage: molecular and cell biology, biotechnology, biomedical engineering, immunology, nanotechnology.

How to apply

All applications should be made online at Under programme name Cardiopulmonary Regenerative Engineering.

Please quote reference number: SAM27.

Funding Notes

Applicants who apply for this project will be considered on a competitive basis in March 2020 against candidates shortlisted for this and other projects with the advert reference beginning ‘SAM’. Early submission is advised, and a complete application must be received before the advert’s closing date.

If successful, candidates will be awarded a 3-year school studentship providing a tax-free stipend and tuition fees at the UK/EU rate (currently £15,009 and £4,327, respectively, in 2019-20 which are likely to rise by 2020/21). Non-EU-nationals may apply but the studentship will cover the cost of the international tuition fee only.

Successful candidates will be notified by 26 March 2020.

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