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Development of a high throughput screening platform for the discovery of novel ECM mimic

Project Description

This three-year PhD project is between the School of Pharmacy and the School of Medicine. This project builds upon the highly successful high throughput screening programme established at the University of Nottingham to discover novel biofunctional materials that can mimic extracellular matrix and can be applied clinically to improve wound healing. This project seeks to expand the library of the materials available for high throughput screening beyond synthetic materials that interact with biological systems passively to biofunctionalised materials that can direct the behaviour of cells.
The project is multi-disciplinary combining materials chemistry and surface analysis with cell culture. Furthermore, the project will be highly applied and will focus on producing outcomes that can be commercially utilised. Advanced surface analysis techniques such as time of flight secondary ion mass spectrometry and atomic force microscopy will be central to the characterisation and development of the materials generated in this project. At the same time, this project will develop skills in cell culture and characterisation of cell phenotypes using microscopy.

Funding Notes

Due to funding restrictions, the position is only available for UK candidates. Candidates must possess or expect to obtain, a 2:1 degree in engineering or science related discipline. The project is particularly suitable for candidates with a materials or chemistry background who would like to continue developing their materials chemistry skills while expanding to cell culture methods.

How good is research at University of Nottingham in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 44.10

Research output data provided by the Research Excellence Framework (REF)

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