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Development of a regime map for the process of seeded granulation

About This PhD Project

Project Description

Granulation of powders is a key unit operation in many chemical industries. In particular, the detergent and pharmaceutical processing industries, where uniform granular products are essential for optimum operation of the active ingredients contained within the particles. Seeded granulation was recently introduced. In this process large particles present in the feed act as seeds in the granulation. It has been shown that seeded granulation produces granules with narrower distributions of granule size, uniform strength and density. The potential application of the seeded granulation process in the chemical and pharmaceutical industry requires a detailed study of the analysis of wet granulation process to discover the best operation window for production of seeded granules. The aim of this project is to develop process-product relationship to produce functional chemical and/or pharmaceutical products. The particular goal is to develop and enhance understanding of the mechanism for seeded granulation by identifying the key parameters responsible for controlling the process in high shear granulators. Applications include high added value materials with significant commercial impact such as pharmaceutical, nutraceutical and detergent powders.

Research aims & objectives
The project is focused mainly on experimental work, however use of EDEM or gSOLID software is also recommended to get insight to the process and discover process-product relationship and develop a regime map of the process.

Applications and expressions of interest are invited from prospective researchers with a good background of chemical engineering or a closely related field.

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