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Development of a spatially resolved spectroscopy probe for application in pharmaceutical drying processes


Project Description

Despite being the most widely studied PAT technologies, to date, most applications of NIR and Raman spectroscopy are carried out using standard measurement geometry without specifying and differentiating spatial arrangement between the incident and collecting optics. Standard NIR and Raman probes include multiple fibres for delivering incident light and/or collecting the spectra, producing spectra correspond to averaged optical response across a probing area. SORS/SR-DRS separate from the standard Raman and NIR reflectance measurement by the probe design and analysis methodology.

The student will be involved in an exciting project funded by a group of pharmaceutical companies to develop a new approach for performing in-line measurement in the pharmaceutical drying process. As part of the project, an innovative SORS/SR-DRS will be developed to provide a complemented information about the physical and chemical information during the drying process. The project will collaborate with Dr Price’s group to leverage the information gathered and utilise the identified conditions to perform tests on innovative SORS/SR-DRS probe. The student will perform SORS and SR-DRS measurement inline from a drying vessel under a range of drying conditions for combinations of materials and solvents. The collected information will be analysed to develop a robust analysis on estimating particle size distribution and solvent content. Off-line measurements on solvent content and composition will be performed using NMR and GC-MS. The analysis method used for the current SORS and SAR-DRS systems will form the benchmark method and inform the development of an analysis strategy for the proposed SORS/SR-DRS probe. The project is an excellent opportunity for candidates who like to work in a team to develop novel solution with direct influence to address significant industrial challenges.

In addition to undertaking cutting edge research, students are also registered for the Postgraduate Certificate in Researcher Development (PGCert), which is a supplementary qualification that develops a student’s skills, networks and career prospects.

Information about the host department can be found by visiting:

http://www.strath.ac.uk/engineering/chemicalprocessengineering

http://www.strath.ac.uk/courses/research/chemicalprocessengineering/

Funding Notes

This PhD project is initially offered on a self-funding basis, with partial funded provided by an industrial project. It is open to applicants with their own funding, or those applying to funding sources. However, excellent candidates may be considered for a University scholarship.

Students applying should have (or expect to achieve) a minimum 2.1 undergraduate degree in a relevant engineering/science discipline, and be highly motivated to undertake multidisciplinary research.

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