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Development of an enhanced gene therapy for Canavan disease using directed evolution

  • Full or part time
    Dr L Coffey
  • Application Deadline
    Friday, April 26, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

Post summary

Applications are invited for a PhD position funded by the WIT PhD Scholarship Programme, for a 4-year research project “Development of an enhanced gene therapy for Canavan disease using directed evolution”. The candidate is expected to be self-motivated, capable of working on his or her own initiative and fit in with the friendly atmosphere within the wider research team. This PhD Project will use directed evolution to enhance human ASPA enzyme performance, which will inform a potential enhanced gene therapy for the rare genetic disorder Canavan disease. The project will rely on a variety of molecular biology techniques, including PCR, gene sequencing, cloning, gene regulation and expression, mutagenesis and enzyme analysis. The candidate will also analyse potentially enhanced gene therapies using disease models in the US-based Horae Gene Therapy Center with co-supervisor Prof. Guangping Gao. The project is a collaboration between Waterford Institute of Technology and University of Massachusetts Medical School. The PhD project will be for 4 years and will cover fees in addition to a personal stipend and research expenses.

Funding Notes

This is a 4 year full-time structured PhD programme

Stipend: €12,000 p/a
Fees: €4,500 p/a
Research costs: €2,000 p/a

For any informal queries, please contact Lee Coffey, +353 51 302624

For further information on this scholarship and how to apply, please visit View Website

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