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Development of bright nanotags for surface enhanced Raman Scattering


Project Description

Surface enhanced Raman scattering is an extremely sensitive and selective technique that is rapidly emerging as an effective method for ultrasensitive analysis. It offers an increased enhancement over normal Raman scattering therefore is ideal for the detection of trace amounts of analytes. This project will involve exploring the encapsulation of Raman reporter labelled metal nanoparticles, in for example different polymers or silica, to produce optically bright SERS nanotags that can be used as labels in, for example, bioassays and bioimaging. This project, in collaboration with Dstl will develop a system that is able to assess and sort the quality of synthesised nanoparticcles to ensure that they give optimum SERS responses. Therefore, this project will focus on developing labelled SERS active nanotags which give a strong SERS response at 785 nm. This will require synthesising different types of metal nanoparticles which have absorbances towards the infrared region of the electromagnetic nanoparticles and developing coatings for the nanoparticles which are stable in the environment in which they will act as a label. This will involve exploring the encapsulation of labelled nanoparticles in for example different polymers or silica. An approach will then be develop to allow selection and isolation of nanoparticles that give the highest SERS response, likely using a fluidics based approach. Once the system has been optimised to give maximum SERS response, the nanotags will also be used for the development of sensitive bioassays.
This project will involve synthesis and functionalisation of metal nanoparticles, surface enhanced Raman scattering and analytical measurements. Experience in approaches that could be used for nanoparticle separation, such as microfluidics, would also be beneficial.

Funding Notes

This project is funded by EPSRC and DSTL. The funding requirements mean the studentship is open to UK students only.

How good is research at University of Strathclyde in Chemistry?
(joint submission with University of Glasgow)

FTE Category A staff submitted: 35.40

Research output data provided by the Research Excellence Framework (REF)

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