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Development of chemical tools to study and manipulate biological processes in live cells

  • Full or part time
    Dr M Vrábel
  • Application Deadline
    Sunday, February 23, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Chemical reactions compatible with biological systems offer unique possibility to manipulate and study biological processes under native conditions. Our group has a long term interest in these, so-called, bioorthogonal reactions. Within last years, we have developed a series of reactions that enable us to monitor small molecules or biomolecules in living cells based on fluorescent signal formed during the chemical reaction. We also use chemical and biological approaches to produce peptide or glycopeptide libraries that we screen for specific binding to various cellular targets. Within this project, we plan to develop new and employ existing chemical tools to study and answer various biologically relevant questions. The ideal candidate should have background in synthetic organic chemistry but also interest in chemical biology and biochemistry. This interdisciplinary project will enable you to broaden your knowledge in these and related fields and to experience the international environment of the group and the Institute.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2020”:

If you decided to apply, please do so online via our application form:

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options


Vazquez, A., Dzijak R., Dracinsky M., Rampmaier R., Siegl S. J., Vrabel, M. (2017). Mechanism-Based Fluorogenic trans-Cyclooctene-Tetrazine Cycloaddition. Angew. Chem. Int. Ed., 56, 1334-1337.

Siegl, S. J., Dzijak, R., Vazquez, A., Pohl, R., Vrabel, M.: (2017). The Discovery of Pyridinium 1,2,4-Triazines with Enhanced Performance in Bioconjugation Reactions. Chem. Sci. 8, 3593–3598.

Related Subjects

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