Development of dental caries detection point of care tools

About the project: Dental caries is the most common chronic disease in children and represents a significant disease burden for both children and adults. As a largely preventable disease early detection and risk prediction have been identified as useful tools for implementation of control measures. Non-invasive sampling is a highly desirable solution for detection of any disease: in the oral cavity saliva provides this potential as it is a fluid easily collected with minimal intervention. We have previously detected and developed saliva based biomarkers for another highly prevalent oral condition: gum disease/periodontal diseases. In this laboratory based project the PhD candidate will utilise and develop further current pipelines to explore caries detection in children and adults.

Cohort: Samples for exploration will be collected at the Birmingham Dental Hospital via the Dentistry Research Tissue Bank. There is access to a wide range of patients visiting this busy dental hospital.

Techniques: Saliva samples may be explored via a range of techniques including mass spectrometry based proteomics and microbiome analysis. In house equipment can be used for development of rapid tests such as lateral flow tests or other sensing platforms.

Person Specification: Applicants should have a strong background in biological science and/or dentistry. The student will receive extensive interdisciplinary training and experience in techniques in well–equipped state-of-the-art laboratories in the School of Dentistry and across the wider University of Birmingham campus. In addition, training will be provided in scientific writing and presentational skills. The student will play an active role in the vibrant post-graduate community within the School and the broader College and University. The student will also be encouraged to attend relevant conferences both nationally and internationally. The supervisors operate an “open door” policy in addition to the more formal monthly research meetings used to monitor progress and direct work.

To be considered for this studentship, please send the following documents to Dr Melissa Grant m.m.grant@bham.ac.uk in the first instance:

• A detailed CV, including your nationality and country of birth;

• A covering letter highlighting your research experience/capabilities;

• Copies of your degree certificates with transcripts;

• Evidence of your proficiency in the English language, if applicable.