This project aims to develop methodologies to functionalise human cell-derived exosomes, using techniques in molecular biology and cell culture to affect the loading of macromolecular therapeutic cargoes (proteins, DNA, RNA) and cancer targeting molecules. In addition, we aim to investigate the ability of these exosomes to deliver macromolecular therapies and to characterise the anti-tumour effects using common cancer cell lines. Key research methods rely on standard techniques in molecular biology, including bacterial cell cloning, mammalian cell cloning, recombinant protein production and characterisation, Western blot immunodetection, mammalian cell culture, confocal microscopy, flow cytometry, and nanoparticle analysis.
This project is self-funded. Details of studentships for which funding is available are selected by a competitive process and are advertised on our jobs website (View Website) as they become available.