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Development of Functionalised Nanoparticles for Cancer Imaging Using Surface Enhanced Spatially Offset Resonance Raman Spectroscopy (SESORRS)


Project Description

Spatially offset Raman spectroscopy (SORS) is a method used for accurate and robust chemical analysis of objects where the contents are obscured by an opaque layer such as tissue. It involves interrogating a sample with an incident laser beam and measuring the scattered light at a distance offset from the illumination area, this allows Raman responses to be obtained from analytes at depth within a sample. Further advances in deep Raman techniques have led to the combination of both surface enhanced Raman scattering (SERS) and SORS together, referred to as SESORS, which makes use of specifically designed functionalised metal nanoparticles as optical imaging probes to detect signals from even deeper depths through tissue. In addition, our recent paper introduced the concept of SESORRS, where we used metal nanoparticles functionalised with resonant Raman reporters to allow us to obtain SERS signals at depths of 25 mm through tissue and allowed detection of 3D breast cancer tumour models at depths of 15 mm (Chemical Science, 2018, 9, 3788 – 3792)
This project, in collaboration with Dstl, will build on our previous research and will use portable SORS to assess the ability to detect SERS nanotags at greater depths and further develop the approach for biomedical applications.

Funding Notes

Applicants should have a first class or 2.1 Masters degree in Chemistry or Physics or related subject.
Funding for this PhD position is only available for UK citizens. To apply please send a CV and cover letter to

How good is research at University of Strathclyde in Chemistry?
(joint submission with University of Glasgow)

FTE Category A staff submitted: 35.40

Research output data provided by the Research Excellence Framework (REF)

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