About the Project
This project will use DOS to enable the preparation of libraries of NCEs comprising heterocyclic pharmacophores, which will be used to probe the functional activity of unexplored targets. DOS will also be used to discover novel tool compounds to probe regulation and functional activity of (i) aldehyde dehydrogenase (ALDH) isoforms highly expressed in cancer stem cells, (ii) cytochrome P450 (CYP) isoforms expressed in solid tumours or (iii) aldo-keto reductase 1C3 (AKR1C3). Conventional approaches such as computational modelling and medicinal chemistry will be employed in parallel to the use of DOS in order to develop chemical probes for enzyme interrogation. Effective chemical tool compounds will be modulated with the aim to develop fluorophores with commercial potential and/or tumour selective therapeutics with clinical potential to treat cancer patients.
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