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Development of Luminescent Carbohydrate-Based Sensors

  • Full or part time
  • Application Deadline
    Tuesday, April 30, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Applications are invited from suitably qualified candidates for a PhD position under the supervision of Dr Joseph Byrne, School of Chemistry, National University of Ireland Galway. This position is funded by a Science Foundation Ireland Starting Investigator Research Grant (SIRG) and is available to start as soon as possible. The successful candidate will work under the direction of Dr Joseph Byrne, with Prof Paul Murphy acting as co-supervisor. The research programme will involve collaboration with researchers at the Centre for Research in Medical Devices (CÚRAM).

The recruited PhD student will focus on synthesis, purification and characterisation a family of carbohydrate-based luminescent sensors, and determining characteristic binding profiles of these compounds with carbohydrate-binding proteins, such as those associated with pathogenic bacteria. They will conduct photophysical characterisation of the sensor molecules in solution and will characterise the anti-biofilm activity of the carbohydrate-containing molecules. The project will develop functional materials for use in innovative diagnostic technologies. They will also gain interdisciplinary training and proficiency in glycochemistry and the production of biomedical devices.

Duties: • Design and synthesis of carbohydrate-based luminescent molecules and materials

• Candidates should have excellent communication and organisational skills; be highly motivated and passionate about developing new products; and have strong documentation, oral and interpersonal skills.

• PhD students normally enter the School of Chemistry structured programme
• Applicants should be aware that PhD students contribute to the teaching of undergraduates in the School of Chemistry at NUI Galway
Qualifications/Skills required: • MSc completed (or thesis submitted for examination) in the area of synthetic organic chemistry (or related area). An experienced BSc graduate who has demonstrated outstanding performance in their undergraduate studies and who has obtained experience in using synthetic and analytical techniques will also be considered. They should have at least an introductory knowledge of NMR spectroscopy in structure determination.
• The candidate must have interest in carbohydrate chemistry as well as in medicinal chemistry and synthesis. • It will be an advantage to have an interest in medical devices or materials science.
• The candidate must be a motivated scientist, willing to take initiative in developing their project • Strong communication and interpersonal skills are required as it the ability to work well within a collaborative team Scholarship: € 18,500 per annum with an additional contribution of €5,500 towards fees/levies as per SFI awards regulations. Some travel to appropriate conferences may also be funded.

Start date: As soon as possible between April-October 2019.

Funding Notes

Funding is provided by Science Foundation Ireland and the European Regional Development Fund.

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