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Development of nature-inspired polyester particles for cancer vaccines

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Advances in synthetic biology allows recombinant bacteria to produce protein coated polyester particles. These polyester particles have been utilized as particulate vaccines against bacterial and viral infections. However, their investigation in area of vaccination against cancers still lacks. In this project, polyester particles will be developed in vivo to carry neoantigens derived from tumor tissue of cancer patients. Various surface chemistry modification will be carried out to enhance the efficacy of the particulate vaccines against model cancers in vitro and in vivo.

Funding Notes

About the Scholarship

The 2019 Griffith University Postgraduate Research Scholarship has an annual stipend of $27,596 (indexed) for a period of up to three years of full-time study. Please see the GUPRS Conditions of Award for more information: View Website

A successful International applicant will also be awarded a Griffith University International Postgraduate Research Scholarship to cover tuition fees for up to three years. Please see the GUIPRS Conditions of Award for more information: View Website

References

1. Parlane, N. A.; Gupta, S. K.; Rubio-Reyes, P.; Chen, S.; Gonzalez-Miro, M.; Wedlock, D. N.; Rehm, B. H. A., Self-Assembled Protein-Coated Polyhydroxyalkanoate Beads: Properties and Biomedical Applications. ACS Biomaterials Science & Engineering 2017, 3 (12), 3043-3057.

2. Hu, Z.; Ott, P. A.; Wu, C. J., Towards personalized, tumour-specific, therapeutic vaccines for cancer. Nature Reviews Immunology 2017, 18, 168.

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