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Development of new ligation systems for the preparation of peptide-drug conjugates


Project Description

This PhD project will develop novel antibody-drug or peptide-drug conjugates and new methods for their preparation and will be co-supervised by Sam Butterworth (medicinal chemistry, pharmacology, bioconjugation) and Mike Greaney (organic synthesis, methods development) at the University of Manchester. The project builds on an established program that is developing a novel series of peptide-drug conjugates that selectively target monocytic leukaemias, with a focus on using these molecules as the basis for the development and application of novel broadly-applicable methodologies for bioconjugation. As such the project will involve multi-step organic synthesis, new synthetic method development for bioconjugation (including protein manipulation and purification), as well as optional involvement in pharmacological testing of the conjugates prepared. The work is supported by a CASE award from the medical research charity LifeArc.

Academic background of candidates:
Applicants are expected to hold, or about to obtain, a minimum upper second class undergraduate Masters degree (or equivalent) in chemistry, with research project experience in organic chemistry, medicinal chemistry, or closely related area.

Contact for further Information:
; 0161 275 1310
;

Funding Notes

This is a 3.5 year EPSRC iCASE studentship with LifeArc. The funding will cover fees and stipend (£15,009 in 2019-20).

Open to UK/EU applicants with 3 years residency in the UK only.

We expect the programme to commence in September 2020.

References

• Greaney: Angew. Chem. Int. Ed. 2019, 58, 9826; ACS Catal. 2018, 11, 10032; Angew. Chem. Int. Ed. 2017, 56, 4183;
• Butterworth: Nat. Commun. 2019, 10, 377; Org. Lett. 2015, 17, 1236; J. Med. Chem. 2014, 57, 8249;

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