Development of new therapies for immunothrombotic disease.

The Preston lab (www.prestonlab.com) at RCSI is seeking to recruit 2 x PhD students to join an SFI-funded research programme studying molecular pathways at the interface of blood coagulation and innate immunity.

Immunothrombotic diseases, such as severe sepsis and COVID-19, are characterised by dysregulation of immunity and blood coagulation that can result in severe and life-threatening symptoms. Consequently, our lab seeks to develop new therapeutic approaches to treat patients with these common, but often deadly, conditions.

These PhD studentship projects will apply new approaches to better understand the molecular basis of blood vessel anti-inflammatory signalling pathways and work with international collaborators to characterise novel therapeutic synthetic proteases for potential clinical use. To achieve these aims, students will be trained in state-of-the-art molecular biology techniques, including protein engineering, transcriptomic technologies, CRISPR genomic modification and super resolution microscopy. 

Tenure - how long is it for?

4 year PhD

Mandatory Specification

1st Class or Upper Second Class (2.1) honours degree (or equivalent) in a relevant subject (immunology, biochemistry, molecular biology or similar).

How do I apply

To apply, please access the following link and complete the application form in full:

https://forms.office.com/Pages/ResponsePage.aspx?id=50FwYBKocEa9MDD52yEPBj6BgpLzl-ZNggs5DLWflaNUNEhNQzM1NlFSMFlaUlNYMVhKMVZTOUhNTS4u

• Unfortunately, we are unable to provide individual feedback to applicants.
• Shortlisted candidates will be invited for interview.
• At this stage only successful candidates will be contacted to submit, CV, transcripts and other relevant documentation.
• Only their referees will also be contacted at this stage for a reference.

Applications must include:

(i) a completed application form

(ii) English language requirements – see https://www.rcsi.com/dublin/postgraduate/policies-and-guidelines/english-language-requirements.

Deadline: All applications must be made online by 20 June 2022 (GMT)

It is the candidate’s responsibility to ensure the application form is completed in full on time. Late and/or incomplete applications will not normally be assessed.

Further information on the Royal College of Surgeons in Ireland can be found here: https://www.rcsi.com/