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Development of Novel 3D-Printable Chemical Reaction and Separations Technologies for Continuous Flow Synthesis of Drugs

About This PhD Project

Project Description

In recent years flow chemistry and continuous manufacturing have been the object of increasing interest in the pharmaceutical industry. They offer the potential to improve product quality, while simultaneously reducing costs, increasing flexibility of supply and enabling miniaturization of commercial production. Flow processes offer the ability to utilize novel chemistries for the synthesis of drugs not normally accessible at scale in addition to improved selectivity and productivity. This enables improvement of individual step chemistries and also opens up new synthetic routes for active pharmaceutical ingredients.

This position is part of a research collaboration between UCD Chemical and Bioprocess Engineering, I-form the SFI Advanced Manufacturing Research Centre and Merck Research Labs (Rahway, NJ). The collaboration aims to significantly intensify pharmaceutical synthesis and production through the development of novel 3D-printed reactors and separation unit operations, to facilitate intensified fully telescoped/integrated continuous flow synthesis of drugs, and thereby their manufacture within miniaturized printable chemical factories. The successful candidate will have the opportunity to take on a leadership position in terms of chemical and process engineering within the multidisciplinary team of synthetic & analytical chemists, mechanical & materials engineers and pharmaceutical scientists, based in the UCD O’Brien Science Centre.

The student will work under the supervision of Dr. Steven Ferguson and Dr. Philip Donnellan on the design, optimization and fabrication via 3D-printing of novel flow chemical reactors and purification equipment. The project will combine computational design approaches (CFD & Process simulation) with empirical optimization and rapid prototyping utilizing I-form’s cutting-edge additive manufacturing capabilities. Applications and enquiries should be directed to Dr. Steven Ferguson at the School of Chemical and Bioprocess Engineering, University College Dublin, Ireland ().

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