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Development of novel imaging and simulation technologies for pharmaceutical dissolutiontesting

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  • Full or part time
    Dr Deirdre D'Arcy
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

PhD Studentship in pharmaceutical technology
This project is focused on the development of dissolution imaging and simulation tools to
identify and characterise pharmaceutical particle dissolution behaviour. Application of
shadowgraph imaging (SGI) in particular to dissolution test monitoring will be undertaken.
Combining dissolution imaging with traditional dissolution/release profiles allows greater
insight into the dissolution process through online monitoring. Particles with varying
properties (e.g. particle size; amorphous/crystalline) will be investigated in different
dissolution conditions, with a focus on the flow-through dissolution apparatus. Dissolution
simulation approaches will be investigated through development of our in-house dissolution
simulation software, SimdissoTM. Use of bio- and/or clinically-relevant dissolution test
conditions will explore the value of the SGI and simulation tools in in-vivo predictive
dissolution testing. The student will have exposure to both wet laboratory and computational
simulation tools.
The successful candidate will be registered for a PhD degree in the School of Pharmacy and
Pharmaceutical Sciences, Trinity College Dublin (TCD); the project will be carried out in
collaboration with the co-investigator, Dr. Tim Persoons, in the Department of Mechanical
and Manufacturing Engineering, TCD.
Standard duties and Responsibilities of the Post
The PhD student will carry out an original body of high quality research as part of the
requirements for a PhD at Trinity College. Trinity College runs a structured PhD program. PhD
students are expected to complete taught modules (a minimum of 10 ECTS and a maximum
30 ECTS) to equip them with further research skills. The student will be required to regularly
meet with their supervisor and submit reports, attend and contribute to lab group/school
meetings, communicate research findings at national and international conferences and liaise
with other members of the research/academic staff. Importantly, the student will be required
to publish research findings.

Person Specification
Essential
 A minimum of a 2:1 honours degree or equivalent in pharmacy, pharmaceutical
sciences, chemistry, mechanical/chemical engineering or related disciplines.
 Proficiency in the English language.
 Excellent written and communication skills.
 Highly motivated
 Ability to work independently and as part of a multidisciplinary team
 Flexibility with regard to the research environment
Desirable
 Previous experience of working in a research laboratory environment.
The PhD candidate is expected to commence March 2020.

Please send curriculum vitae including information on your previous research experience and
names, emails and postal addresses of two suitable academic referees, as well as a cover
letter, to:
Assoc. Prof. Deirdre D’Arcy
School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland
[Email Address Removed]
Incomplete applications will not be considered.
Application deadline: 17.00, 15th Nov 2019

Funding Notes

This post is supported by a Provost’s PhD Project Award awarded to Assoc Prof Deirdre
D’Arcy. The Provost’s PhD Project Awards are open to EU and non-EU candidates and include
an annual stipend of €16,000 for four years. These doctoral awards are generously funded
through alumni donations and Trinity’s Commercial Revenue Unit.



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