Development of Novel Intraocular Devices (SAEEDAU19SF)
Cataract is clouding of the lens of the eye, which can lead to vision impairment. The most common cause of cataract is ageing, but it can also develop at early ages in Children. Cataract is the leading cause of avoidable blindness and is considered as a major priority in the global initiative to eliminate avoidable blindness by the year 2020. Although cataract can surgically be treated to restore high-quality vision, posterior capsule opacification (PCO), most common complication of the surgery, can develop in a significant proportion of patients and may lead to secondary blindness.
Work carried out by our group, and others have highlighted some of the underlying mechanism and potential therapeutic benefit of clinically approved drugs developed as implantable devices (Healthcare Technologies, EPSRC).
This PhD research project will be aimed at the design and development of novel devices to restore vision and prevent PCO by targeting the pharmacological receptors in the posterior segment of the capsule of the eye. The student will gain experience into the smart drug delivery system and implant, from design and formulation to pre-clinical testing in human eye model. Conducting synthesis and fabrication of polymeric-based drug delivery system, design and optimisation of the drug release profile and investigating the performance of the novel drug delivery system in the human capsular bag model available in our lab.
For more information on the supervisor for this project, please go here: https://people.uea.ac.uk/en/persons/aram-saeed
Type of programme: PhD
Project start date: October 2019
Mode of study: Full time
Entry requirements: Acceptable first degree - Pharmacy or Chemistry. The standard minimum entry requirement is 2:1.
This PhD project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at http://www.uea.ac.uk/study/postgraduate/research-degrees/fees-and-funding.
A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.
i) Julie A. Eldred, David J. Spalton, and I. Michael Wormstone. An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opaciﬁcation Using a Human Capsular Bag Model. IOVS j November 2014 j Vol. 55 j No. 11 j 7058.
ii) Ali Mohammed Alhalafi. Applications of polymers in intraocular drug delivery systems. Oman J Ophthalmol. 2017 Jan-Apr; 10(1): 3–8.
iii) Saeed, A. O., Newland, B., Pandit, A. & Wang, W. X. The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage. Chemical Communications, 2012 48, 585-587.
iv) iv) Liao, X., Walden, G., Falcon, N. D., Donell, S., Raxworthy, M., Wormstone, M., Riley, G. P. & Saeed. A direct comparison of linear and star-shaped poly(dimethylaminoethyl acrylate) polymers for polyplexation with DNA and cytotoxicity in cultured cell lines. European Polymer Journal. Volume 87, February 2017, Pages 458-467