Organocatalysis, or catalysis by small organic molecules, is an area that in the last two decades witnessed an exponential growth. Its importance was recognised in 2021 by the award of Novel Prize to two prominent researchers, David MacMillan and Benjamin List, who were at the forefront of the development of asymmetric organocatalysis. Over the years, the group of Prof Andrei Malkov was active in designing novel organocatalysts for efficient synthesis of functional molecules and key building blocks for important practical applications. This project will continue to explore the area of asymmetric Lewis base organocatalysis.
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The group of Prof. Andrei Malkov has a successful track record in designing novel organocatalysts. Among others, a family of symmetrical bipyridine N,N’-dioxides has been introduced as highly successful Lewis base catalysts for the asymmetric allylation and propargylation of carbonyl compounds. This project aims to extend this family of catalysts with non-symmetrical analogues to enable better flexibility for tuning their electronic and steric properties for application in catalytic processes that are unknown or remain challenging. This will involve:
- Development of coupling protocol for the synthesis of new non-symmetrical bipyridines.
- Optimisation of the catalyst structure for crotylation of aldehydes with deactivated functionalised allylsilanes.
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For further information on the project, the applicants are welcome to inquire informally by e-mail. Find out more about the current research activity of Prof Malkov here.
Entry requirements for United Kingdom
Applicants should have, or expect to achieve, at least a 2:1 honours degree (or equivalent) in chemistry. A relevant master’s degree and/or experience in one or more of the following will be an advantage: synthetic organic chemistry, asymmetric catalysis, organic reaction mechanisms.
Please see the programme website for international entry requirements by country.
English language requirements
Applicants must meet the minimum English language requirements. Further details are available on the International website.
HOW TO APPLY
All applications should be made online. Under programme name, select 'Chemistry'. Please quote reference number: AM/CM/2022