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Development of novel metabolic therapies for glioblastoma

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  • Full or part time
    Prof Tracy Warr
    Dr M Morris
    Dr A Karakoula
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Applications are invited for this fully funded PhD studentship in Molecular Neuro-oncology.

Glioblastoma is a complex and aggressive malignant brain tumour that is characterised by rapid growth, invasion into the normal brain and significant intra- and inter- tumour heterogeneity. This diversity impacts on the efficacy of standard multi-modality treatment including surgical resection, adjuvant chemotherapy and targeted or whole brain radiation and median survival is only 14 months from diagnosis.

The Brain Tumour Research Group at the University of Wolverhampton has identified metabolic processes that are universally disregulated in glioblastoma and which can be used as druggable targets. Working with our experienced team of cell and molecular biologists, this PhD project will investigate the efficacy of novel metabolic therapies to selectively kill glioblastoma tumour cells and to understand the molecular mechanisms of their action. Repurposed drugs and agents in early phase clinical trials for other cancers as well as novel experimental compounds will be assessed in patient-derived preclinical tumour models.

Application process

We are looking for exceptional applicants who hold at least a 2:1 Degree (or equivalent) or have a Master’s level qualification in a biological or biomedical-related discipline. Applicants are invited to submit an application form with names of three academic referees who may be contacted immediately, together with a 250-word summary that sets out clearly how your qualifications and career aspirations match the subject area.

Apply here:

A complete application will consist of the following documents:
 A fully completed application form
 Summary form (max 250 words)
 Academic referees form

Completed applications should be submitted by email to [Email Address Removed] by Monday 19th August 2019.
All short-listed applicants will be interviewed either in person at the University, if based in the UK, or by telephone/Skype if they are based overseas. The studentship is available for an immediate start.

PhD Terms and Conditions: please note that all bursaries offered are subject to the University regulations and continuation from one year to the next is contingent on satisfactory progress.

Funding Notes

The stipend for the studentship will be £15,009 pa for three years with home/EU tuition fees paid. Applicants from non-EU countries will be expected to pay the difference between the full overseas tuition fee and the UK/EU tuition fee. There will also be a contribution to research expenses including travel to conferences.

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