Development of physically stable amorphous solid dispersions (Solid state pharmaceuticals)

Binary thermodynamic phase diagrams (PDs) for drug/polymer systems provide an understanding of the relationship between formulation composition, temperature and phase separation, thus providing a framework for the design of optimal amorphous solid dispersions. The most established experimental approach to the PD construction is based on thermal analysis, however, due to the existence of a wide range of drugs and polymers with diverse physicochemical characteristics, no one-size-fits-all approach can be employed for every drug/polymer combination. The overarching objective of this project is to generate knowledge and expertise in creating DPs based on a range of drugs and polymers with varying physicochemical properties informing the design of a stable amorphous product.

Standard duties and responsibilities:
The PhD student will carry out high quality research collaboratively with a multinational pharmaceutical company, BMS. S(he) will also engage in the structured component of the degree, as required by the university. The student will be involved in training, education and public engagement and any other suitable activities enhancing their professional development. In addition, the student will be required to attend regular meetings with the supervisory team consisting of the academic and industrial supervisors, prepare presentations, write reports, communicate and disseminate information/research findings at conferences and publish research findings.

Person specifications:
Essential
• At least a 2.1 honors degree in pharmacy, chemistry, pharmaceutical/material sciences, chemical engineering, physics or a related discipline.
• Proficiency in the English language
• An aptitude/strong interest in pharmaceutics research
• Excellent written and communication skills
• Highly motivated
• Ability to work independently and as part of a multidisciplinary team
• Flexibility with regard to the research environment

Desirable
• Previous research experience is desirable.