Development of the face (GRIFFINU20DTP)

Applications are invited from motivated and ambitious candidates to join a cutting-edge investigation of the function of Rapgef5 during craniofacial development. Craniofacial birth defects are associated with over 700 human congenital syndromes, and are a leading cause of infant morbidity and mortality. However, despite their impact on child health, our understanding of how the head normally develops, and how these processes are disrupted in disease, remains limited. Discovering the genetic and cellular mechanisms that regulate craniofacial development is a critical first step towards improving treatment and patient prognosis. We recently identified the guanine nucleotide exchange factor Rapgef5 as an exciting new regulator of craniofacial development.

The successful candidate will use CRISPR/CAS9 mediated gene editing, state of the art imaging, genetic and molecular biology techniques to thoroughly investigate the function of Rapgef5 and generate new understanding of the mechanisms regulating development of the head.

Project supervisor: https://www.uea.ac.uk/biological-sciences
Project sponsor: Norwich Research Park Bioscience Doctoral Training Partnership
Type of programme: PhD
Start date: 1 October 2020
Mode of study: Full-time
Studentship length: 4 years


ELIGIBILITY REQUIREMENTS

- First degree (2:1 or above) in relevant subject
- English language (IELTS 6.5 overall, 6 in each section)


MORE INFORMATION

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 7th, 8th or 9th January 2020.

The NRP DTP offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.

For further information and to apply, please visit our website: https://biodtp.norwichresearchpark.ac.uk/