Biopharmaceuticals have been increasingly used in the treatment of skin diseases. However, due to the poor absorption of peptide and protein through the skin, they are usually delivered through injections.
Encapsulation of protein in liposomes has been reported to provide a potential transdermal delivery system. Aspects such as sizing, lipid content and permeation enhancers could further improve the absorption of proteins through the skin.
The project involves the preparation of a nano liposomal drug delivery system using microfluidic reactors. The product will be tested in vitro using skin cell lines for efficacy and geno-toxicity. The project will be running in collaboration with the skin disease unit in St Lukes Hospital, Bradford, with a potential to expand the project into clinical trials.
Applicants are expected to be highly motivated and interested in research area involving aspects of drug delivery and cell cultures.
You will join our Cell and Molecular Biology Research Group, which studies molecular mechanisms important for cellular function in health and disease with a special emphasis on chronic diseases such as obesity, type II diabetes, cardiovascular disease, cancer and infertility.
This is a self-funded PhD project; applicants will be expected to pay their own fees or have a suitable source of third-party funding. A bench fee also applies in addition to tuition fees.