About the Project
The Carnegie School of Sport in collaboration with DexaStrong is looking to recruit a highly motivated individual to a prestigious PhD Studentship in the reserach area Novel osteogenic loading alongside nutrition and exercise interventions for optimisation of musculoskeletal and metabolic health in post-menopausal women.
The quality of Carnegie School of Sport research is evident in the outstanding results achieved in the 2021 Research Excellence Framework, where we ranked 2nd nationally when accounting for both research quality and the number of contributing staff.
Full-time Sponsored PhD Studentship / Start date: February 2023 / The Studentship will be based in Leeds
Novel osteogenic loading alongside nutrition and exercise interventions for optimisation of musculoskeletal and metabolic health in post-menopausal women (PhD1)
Musculoskeletal and metabolic health may be compromised in certain populations such as post-menopausal women and older adults. Deficiencies in dietary protein intake and 25-hydroxyvitamin D3, which are critical, but not exclusive, for optimisation of muscle and bone health, are also highly prevalent in these groups of people. Proof-of-concept research involving novel means of osteogenic loading (i.e., bioDensity apparatus) suggests that bioDensity may improve musculoskeletal and metabolic health. Considering that optimisation of musculoskeletal and metabolic adaptations depend upon nutritional support and overall physical activity/exercise levels, there is scope for further research to investigate the efficacy and effectiveness of the bioDensity apparatus singularly or combined with exercise and nutrition interventions.
The aims of this research will be to explore and discover how we can best use and integrate the bioDensity alongside exercise/physical activity and novel nutritional interventions to optimise musculoskeletal and metabolic health.
The work is primarily aligned with the SARCA Theme of the Active Lifestyles Research Centre.
Applicants are encouraged to discuss their applications and project proposal with Dr Theocharis Ispoglou ([Email Address Removed]) and Dr Matthew Barlow ([Email Address Removed])
For further information on how to apply please visit here
References
Ispoglou, T., et al., The efficacy of essential amino acid supplementation for augmenting dietary protein intake in older adults: implications for skeletal muscle mass, strength and function. Proc Nutr Soc, 2020: p. 1-13.
Lees, M.J., et al., Muscle quality as a complementary prognostic tool in conjunction with sarcopenia assessment in younger and older individuals. Eur J Appl Physiol, 2019. 119(5): p. 1171-1181.
Lees, M.J., et al., Novel Essential Amino Acid Supplements Following Resistance Exercise Induce Aminoacidemia and Enhance Anabolic Signaling Irrespective of Age: A Proof-of-Concept Trial. Nutrients, 2020. 12(7).
Ispoglou, T., et al., Novel essential amino acid supplements enriched with L-leucine facilitate increased protein and energy intakes in older women: a randomised controlled trial. Nutrition Journal, 2017. 16(1): p. 75.
Ispoglou, T., et al., Double-blind, placebo-controlled pilot trial of L-Leucine-enriched amino-acid mixtures on body composition and physical performance in men and women aged 65-75 years. European Journal of Clinical Nutrition, 2016. 70(2): p. 182-8.
Hung, Y.-L., et al., Influence of oestrogen on satellite cells and myonuclear domain size in skeletal muscles following resistance exercise. Journal of Cachexia, Sarcopenia and Muscle. n/a(n/a).
Kissow, J., et al., Effects of Follicular and Luteal Phase-Based Menstrual Cycle Resistance Training on Muscle Strength and Mass. Sports Medicine, 2022.
Harding, A.T., et al., The LIFTMOR-M (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men) trial: protocol for a semirandomised controlled trial of supervised targeted exercise to reduce risk of osteoporotic fracture in older men with low bone mass. BMJ Open, 2017. 7(6): p. e014951.
Bemben, D., et al., Relevance of Whole-Body Vibration Exercises on Muscle Strength/Power and Bone of Elderly Individuals. Dose-response : a publication of International Hormesis Society, 2018. 16(4): p. 1559325818813066-1559325818813066.
Kirk, B., J. Zanker, and G. Duque, Osteosarcopenia: epidemiology, diagnosis, and treatment—facts and numbers. Journal of Cachexia, Sarcopenia and Muscle, 2020. 11(3): p. 609-618.
Giannos, P., Prokopidis, K., Church, D., Kirk, B., Morgan, P., Lochlainn, M., . . . Ispoglou, T. (2022). Associations of bioavailable serum testosterone with cognitive function in older men: results from the National Health and Nutrition Examination Survey. Journal of Gerontology Series A: Biological Sciences and Medical Sciences. https://pubmed.ncbi.nlm.nih.gov/35927217/
Prokopidis, K., Giannos, P., Ispoglou, T., Witard, O. C., & Isanejad, M. (2022). Dietary fiber intake is associated with cognitive function in older adults: Data from the National Health and Nutrition Examination Survey. The American Journal of Medicine. https://pubmed.ncbi.nlm.nih.gov/35367443/
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