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Diet mediated metabolic-inflammation & cancer risk

Project Description

Background and significance of research:

Metabolic-inflammation is a critical process that underpins cancer biology. In the last number of years, the Roche Nutrigenomics team has demonstrated that different dietary fats can re-configure metabolic-inflammation. This PhD programme will bring this paradigm one step further in terms of understanding the impact of dietary re-configuration of metabolic-inflammation within the context of human oesophageal adenoma carcinoma (OAC).

Research aims:

Investigate the impact of different dietary fatty acids on metabolic-inflammation.

Determine if/how dietary metabolic stressors, such as palm oil and fructose, impact risk of OAC.

Understand whether alternative fats, such as polyunsaturated fats, may attenuate metabolic-inflammation.

Specific skills/experience required by applicants:

The candidate should have a background in biochemistry, immunology, molecular biology or nutrition.

Ideal candidates will have some prior wet lab experience.

This PhD will be conducted in collaboration with Prof Jacinta O’Sullivan (Trinity College Dublin) and the Nutrigenomics Group at University College Dublin (UCD). It is anticipated that the PhD candidate will spend some time working in TCD / UCD, particularly in relation to human adipose and OAC tumour analysis.

Funding Notes

UK and EU students are eligible to apply. Information on eligibility criteria is available from DfE: View Website

International applicants are welcome to apply, as additional funding may become available to cover fees at the higher rate.

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