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Diet mediated metabolic-inflammation – mechanistic insights

  • Full or part time
  • Application Deadline
    Monday, December 16, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Project details:

Metabolic-inflammation is a critical process that underpins obesity related disease including diabetes and cancer biology. In the last number of years, the Roche Nutrigenomics team has demonstrated that different dietary fats can re-configure metabolic-inflammation. This PhD programme will bring this paradigm one step further in terms of understanding the impact of dietary re-configuration of metabolic-inflammation, which may then be elaborated within the context of diabetes and/or oesophageal adenoma carcinoma (OAC).

Diet is a key determinant of diabetes and cancer risk. Epidemiological evidence suggests that obesity greatly increases risk of both conditions. However, not all diets, or dietary components, may not have adverse health effects. This PhD programme will determine if some fatty acids are particularly deleterious and conversely if others (PUFA) are not. This will then provide mechanistic evidence in relation to how diet may be re-configured, in order to prevent conditions such as diabetes or cancer and promote health.

This PhD will:

1. Investigate the impact of different dietary fatty acids on metabolic-inflammation.
2. Determine if/how dietary metabolic stressors, such as palm oil and fructose, impact metabolic-inflammation.
3. Define whether alternative fats, such as polyunsaturated fats, or other novel nutrients, may attenuate metabolic-inflammation.

This project will be supervised by Professor Helen Roche and Dr Qiaozhu Su of Queen’s University School of Biological Sciences/Institute for Global Food Security.

Applications MUST be submitted through

Specific skills/experience required by applicants:

The candidate should have a background in biochemistry, immunology, molecular biology or nutrition. Ideal candidates will have some prior wet lab experience.

All applicants must meet the academic entry requirements:

Funding Notes

Only UK and EU students are eligible to apply. Before applying, it is strongly recommended that you read the full information on eligibility criteria available from DfE: View Website.

Please note in particular that not all successful applicants may be eligible to receive a full studentship (i.e. fees and stipend) - please read in detail the Residency and Citizenship requirements in the document linked to above.

How good is research at Queen’s University Belfast in Agriculture, Veterinary and Food Science?

FTE Category A staff submitted: 33.40

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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