MONDAY 22 JUNE12-4PM BSTOver 60 universities | Funding advice | Virtual talksRegister now
Imperial College London Featured PhD Programmes
University of Exeter Featured PhD Programmes
Life Science Zurich Graduate School Featured PhD Programmes

Diffusion Ordered Spectroscopy NMR for the Rapid Identification of Medicinal Plants


Faculty of Science, Engineering and Computing

About the Project

Diffusion Ordered Spectroscopy (DOSY) is a nuclear magnetic resonance (NMR) technique that is used to analyse mixtures.[1–3] Put simply, NMR signals that overlap in 1D NMR spectra are separated in 2D DOSY spectra according to molecular size and those that belong to the same component align as they are governed by the same diffusion coefficient. DOSY can offer information about the number of components in the mixture and allows extraction of 1D spectra of individual components as well as determination of their molecular weights.[4,5]

The identification of components in a mixture by NMR provides several advantages over other instrumentation techniques, like high-performance liquid chromatography-mass spectrometry (HPLC-MS), such as being non-destructive and requiring minimal sample preparation.

This project will the investigate and optimise the most recent DOSY NMR techniques for the screening of plants with medicinal potential.[6,7,3] Experience in the use of conventional 1D and 2D NMR techniques (HSQC, HMBC) and their application to the identification of small organic molecules, is a prerequisite for those interested in this opportunity. An interest in natural product chemistry is desirable.

Funding Notes

There is no funding for this project

References

[1] H. Barjat, G. A. Morris, S. Smart, A. G. Swanson, S. C. R. Williams, J. Magn. Reson. B 1995, 108, 170–172.
[2] C. S. Johnson, Prog. Nucl. Magn. Reson. Spectrosc. 1999, 34, 203–256.
[3] M. Foroozandeh, L. Castañar, L. G. Martins, D. Sinnaeve, G. D. Poggetto, C. F. Tormena, R. W. Adams, G. A. Morris, M. Nilsson, Angew. Chem. Int. Ed. 2016, 55, 15579–15582.
[4] R. Neufeld, D. Stalke, Chem. Sci. 2015, 6, 3354–3364.
[5] A. J. Simpson, Magn. Reson. Chem. 2002, 40, S72–S82.
[6] A. Le Gresley, G. Broadberry, C. Robertson, J.-M. R. Peron, J. Robinson, S. O’Leary, J. Anal. Appl. Pyrolysis 2019, 140, 281–289.
[7] E. D. Rodrigues, D. B. da Silva, D. C. R. de Oliveira, G. V. J. da Silva, Magn. Reson. Chem. 2009, 47, 1095–1100.


Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to Kingston University will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully



Search Suggestions

Search Suggestions

Based on your current searches we recommend the following search filters.



FindAPhD. Copyright 2005-2020
All rights reserved.