About the Project
The identification of components in a mixture by NMR provides several advantages over other instrumentation techniques, like high-performance liquid chromatography-mass spectrometry (HPLC-MS), such as being non-destructive and requiring minimal sample preparation.
This project will the investigate and optimise the most recent DOSY NMR techniques for the screening of plants with medicinal potential.[6,7,3] Experience in the use of conventional 1D and 2D NMR techniques (HSQC, HMBC) and their application to the identification of small organic molecules, is a prerequisite for those interested in this opportunity. An interest in natural product chemistry is desirable.
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 M. Foroozandeh, L. Castañar, L. G. Martins, D. Sinnaeve, G. D. Poggetto, C. F. Tormena, R. W. Adams, G. A. Morris, M. Nilsson, Angew. Chem. Int. Ed. 2016, 55, 15579–15582.
 R. Neufeld, D. Stalke, Chem. Sci. 2015, 6, 3354–3364.
 A. J. Simpson, Magn. Reson. Chem. 2002, 40, S72–S82.
 A. Le Gresley, G. Broadberry, C. Robertson, J.-M. R. Peron, J. Robinson, S. O’Leary, J. Anal. Appl. Pyrolysis 2019, 140, 281–289.
 E. D. Rodrigues, D. B. da Silva, D. C. R. de Oliveira, G. V. J. da Silva, Magn. Reson. Chem. 2009, 47, 1095–1100.
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EPSRC funded DTP: Developing time-gated Fourier Transform Raman micro-spectroscopy and data analysis for the cell sorter - Identification and sorting of cells by their chemical fingerprint