About the Project
Transient receptor potential canonical (TRPC) 1/4/5 channels are found in many cell types including the nervous and cardiovascular systems, where they form nonselective cationic channels with high calcium permeability. Structural and mechanical knowledge of these channels is rapidly evolving, suggesting TRPC1/4/5 assemblies play crucial roles in human physiology and pathology, and consequently are potential drug targets for renal failure, anxiety, cancer, pain, and cardiac remodeling.
Our goal is to study the dynamic structural changes in TRPC1/4/5 assemblies reconstituted into near-native membranes as a function of modulators by high speed AFM. The mechanisms we aim to uncover will not only be applicable to TRPC but also to all other TRP and heteromeric ion channels for which structural information is scarce and will therefore have important implications for general channel physiology and pharmacology. This highly interdisciplinary research will be performed in the School of Physics and Astronomy at the University of Leeds in collaboration with researchers in Leeds Institute of Cardiovascular and Metabolic Medicine.
Funding Eligibility - International Students – China Scholarship Council-University of Leeds Scholarship Award, School of Physics & Astronomy Fee Only Scholarship paying Academic Fees for 3 years, Commonwealth Scholarship and Commonwealth Split Site Scholarships. Alumni Bursary is available to previous University of Leeds graduates offering 10% discount on Academic Fees.
Self-funded students are also very welcome to apply
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