University of Birmingham Featured PhD Programmes
University of Portsmouth Featured PhD Programmes
Anglia Ruskin University Featured PhD Programmes
National University of Ireland, Galway Featured PhD Programmes
University of Manchester Featured PhD Programmes

Discovering and engineering new post-translationally modified antimicrobial peptides

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr J Gutierrez
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

About This PhD Project

Project Description

Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a very attractive alternative to antibiotics for controlling bacterial pathogens as they display a broad spectrum of antimicrobial activity and rarely develop bacterial resistance and/or cause toxicity in eukaryotic cells. The aim of this project is to exploit competitive microbial environments for the discovery of novel RiPPs with relevant antibacterial activity, and understand the mechanisms that regulate their antimicrobial production.

The use of these competitive environments is also crucial to elucidate the mechanisms that the pathogens use to become tolerant (resistant) to antimicrobials. The second aim of this project is to engineer RiPPs in food-grade bacteria as a platform for the production of novel antimicrobials of interest to the food and pharmacy industry.

FindAPhD. Copyright 2005-2019
All rights reserved.