About the Project
Objective: To investigate the molecular and genetic basis of central nervous system regeneration.
Methods: We will use the fruit-fly Drosophila as a model organism. We will use a combination of genetics, molecular cell biology including CRISPR/Cas9 gene editing technology and transgenesis, microscopy, including laser scanning confocal microscopy and calcium imaging of neuronal activity in time-lapse, computational imaging approaches for analysis of images and movies, stimulating and inhibiting neuronal function in vivo using optogenetics and thermogenetics, and recording and analysing fruit-fly behaviour. Ultimately, the findings from our research will have implications beyond Drosophila, with an impact also in understanding how any brain works, in health, injury or disease, including the human brain.
Either way, please contact Prof Alicia Hidalgo directly at : [Email Address Removed]
And please submit an official application online following the link below.
Kato K, Losada-Perez M, Hidalgo A (2018) The gene network underlying the glial regenerative response to central nervous system injury. Developmental Dynamics DOI 10.1002/dvdy.24565
Hidalgo A and Logan A (2017) Go and stop signals for glial regeneration. Current Opinion in Neurobiology 47, 182-187
Losada-Perez, Harrison, Hidalgo (2016) Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki. Journal of Cell Biology 214 (5) 587-601.
Kato K, Forero MG, Fenton JC and Hidalgo A (2011) The glial regenerative response to central nervous system injury is enabled by Pros-Notch and Pros-NFkB feedback. PLoS Biology 9: e1001133
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.