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Discovering new DNA repair enzymes using archaea as a model for mammals


   School of Life Sciences


Nottingham United Kingdom Biochemistry Genetics Microbiology Medicine

About the Project

This PhD research project will combine protein biochemistry and molecular biology methods, and will provide detailed training into how to analyse gene and protein function. It will analyse and define catalytic and DNA binding activities of proteins identified in archaea with homologues in mammals that are associated with DNA repair and genome stability diseases. The project will focus on putative nuclease and helicase enzymes. Further information, including references, can be obtained from Dr. Edward Bolt ().

The University of Nottingham is one of the world’s most respected research-intensive universities, ranked 8th in the UK for research power (REF 2014). Students studying in the School of Life Sciences will have the opportunity to thrive in a vibrant, multidisciplinary environment, with expert supervision from leaders in their field, state-of-the-art facilities and strong links with industry. Students are closely monitored in terms of their personal and professional progression throughout their study period and are assigned academic mentors in addition to their supervisory team. The School provides structured training as a fundamental part of postgraduate personal development and our training programme enables students to develop skills across the four domains of the Vitae Researcher Development Framework (RDF). During their studies, students will also have the opportunity to attend and present at conferences around the world. The School puts strong emphasis on the promotion of postgraduate research with a 2-day annual PhD research symposium attended by all students, plus academic staff and invited speakers.

Funding Notes

Self-funded students or those applying for scholarships are invited to apply. Applicants need to have secured funding, or must have already applied for funding, to be considered for this PhD.
Home applicants should contact the supervisor to determine the current funding status for this project. EU applicants should visit the Graduate School webpages View Website for information on specific EU scholarships. International applicants should visit our International Research Scholarships page View Website for information regarding fees and funding at the University.

References

References provided on enquiry or by potential applicants.

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