Postgrad LIVE! Study Fairs

Southampton | Bristol

University of Manchester Featured PhD Programmes
Birkbeck, University of London Featured PhD Programmes
University of Kent Featured PhD Programmes
University of Warwick Featured PhD Programmes
University of Reading Featured PhD Programmes

Discovering new drug targets in the Sphingolipid biosynthesis pathway of protozoan parasites

Project Description

Protozoan parasites are a diverse group of pathogens responsible for diseases ranging from Malaria (Plasmodium spp.) and Toxoplasmosis (Toxoplasma gondii) to the neglected tropical diseases Leishmaniases (Leishmania spp), Chages disease (Trypanosomas cruzi). In spite of considerable efforts over the last decade, treatment options remain limited. Recently, we have identified enzymes involved in the sphingolipid biosynthesis as potential novel drug targets (Norcliffe, et al. Sci Rep (2018) 3938; Mina et al. (2017) 292:12208-19). The aim of this project is to characterize these enzymes from different species by biochemical, biophysical and structural methods ranging from X-ray crystallography to small angle X-ray scattering and cryo Electron Microscopy. The successful candidate will be based in Durham and the project offers the opportunity of placement with our GCRF partners in Kolkata and/or Rio de Janeiro.

Applicants will need to be in possession of an undergraduate degree at a 2:1 honours level or above (or equivalent) in a discipline directly relevant to the research areas of chemistry and biology.

Interested applicants should send a CV (no longer than 2 pages, and should include the contact details of 2 references) and a short cover letter to Dr. Ehmke Pohl (, or on twitter @ehmke_pohl

Funding Notes

Annual stipend of £14,777. Fees paid.

How good is research at Durham University in Biological Sciences?

FTE Category A staff submitted: 39.00

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully

FindAPhD. Copyright 2005-2019
All rights reserved.