About the Project
Primary focus will be on the discovery of new hypoxia-activated prodrugs (HAPs) and antibody-based fusion proteins labelled with a fluorophore or a cytotoxin that can be used to explore solid tumour microenvironment in vitro (3D spheroids) and in vivo (xenografts). In order to investigate the influence of HAPs in angiogenesis (formation of blood vessels), co-culture of 3D spheroids in combination with endothelial cells will be set up under normoxic and hypoxic conditions. Both efficacy and toxicity of HAPs will be assessed by quantification of tubule formation. Through external collaboration there is also an option to investigate novel therapeutics in combination with radiotherapy.
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Formulation and evaluation of umbilical cord-derived mesenchymal stem cells exosomes and antioxidants, incorporated in nanoliposomes using microfluidics, for the treatment of solid tumours
University of Bradford