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Discovery of small molecules with bactericidal antomycobacterial activity against MDR strains


About This PhD Project

Project Description

Based on the structure of marine natural products showing some anti-tubercular (bacteriostatic) activity, we identified small molecules that exhibit bactericidal activity against Mycobacterium tuberculosis and other pathogens. The core structure of the molecules has several stereogenic centers. Antibacterial effect of our new compounds on Mycobacterium smegmatis cells, including persisters, is potentiated during cell transition to stationary phase.

The work will have a substantial synthetic component that will include stereo- and enantioselective synthetic of the bioactive small molecules. The compounds will be screened for in vitro activity against clinical MDR strains of Mycobacterium tuberculosis, from which lead compounds will be identified. We shall also aim to understand the mechanism by which the small molecules disrupt and/or combat mycobacterial persistence.

Loughborough University

Loughborough University is a top-ten rated university in England for research intensity (REF, 2014) and an outstanding 66% of the work of Loughborough’s academic staff who were eligible to be submitted to the REF was judged as ‘world-leading’ or ‘internationally excellent’, compared to a national average figure of 43%.

In choosing Loughborough for your research, you’ll work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career.

How to apply

All applications should be made online: https://www.lboro.ac.uk/study/postgraduate/apply/research-applications/

Under school/department name, select 'Chemistry'. Please quote reference CM/AM-Un1/2020.

Start dates: October 2020, January 2021

Full-time (3 years)

Fees: Band RB (UK/EU: TBC; international: £22,350)

Entry requirements: Undergraduate upper second class degree or equivalent

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