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  Disease mechanisms in the heart


   Institute of Cardiovascular Sciences

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  Dr Katja Gehmlich  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

We are seeking talented, motivated students with a passion for research in inherited cardiac conditions (cardiomyopathies) and biomechanical stress signalling led by Dr Katja Gehmlich (https://www.birmingham.ac.uk/staff/profiles/cardiovascular-sciences/gehmlich-katja.aspx).

Applicants should have a first or upper second-class degree in a relevant scientific discipline, and who are self-funded or have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.

Research into inherited cardiac conditions and biomechanical stress signalling

The research group of K Gehmlich is embedded in a wider research cluster (5 Principal Investigators) and the research themes “Cardiac diseases” and “Imaging and Technology” within the Institute of Cardiovascular Sciences (ICVS). We are interested in molecular disease mechanisms of cardiac diseases and exploring therapeutic avenues.

Broadly speaking we have four main areas of interest:

•        Understanding the role of Z-disc proteins in biomechanical stress signalling

•        Modelling rare diseases with in vivo and cellular systems

•        Interplay of cardiomyocytes and cardiac fibroblasts in cardiac diseases

•        Ageing of the cardiovascular system

We have ongoing projects examining, e.g.

•        “A disease in a dish” systems for rare metabolic diseases, e.g. Farby disease and Alstrom syndrome 

•        Pathogenic mechanisms of Z-disc protein in cardiomyopathies

•        Understanding the molecular basis of biomechanical stress signalling at the Z-disc

•        The contribution of cell senescence to cardiovascular ageing

We employ in vivo and induced pluripotent stem cell derived cardiomyocyte approaches, including three dimensional engineered heart tissue techniques. We apply a wide range of molecular, functional and –omics techniques, combined with state-of the-art imaging.

PhD projects, using these approaches, answering translationally relevant research questions are available to self-funded or scholarship-funded graduates interested in joining the group.

APPLICATION ROUTES

Self-funded or scholarship-funded graduates interested in joining the team can select one of 3 different routes for undertaking a PhD in the field of Cardiovascular Sciences.

Applicants with research experience and/or Master’s degree should apply directly to the Institute of Cardiovascular Sciences for either a 3 or 4 year full-time PhD – https://www.birmingham.ac.uk/postgraduate/courses/research/med/cardiovascular-sciences.aspx This route requires applicants to submit a drafted research proposal.

Applicants seeking additional research experience or who have yet to complete a Master’s degree should apply to the 4 year Integrated Doctoral Training Programme in Life Sciences for Health, which combined a MRes and PhD – https://www.birmingham.ac.uk/postgraduate/pgr/idtp/index.aspx.

Applicants will need to submit the following documentation during the application process.

•        Detailed CV, including your nationality and country of birth; 

•        Covering letter highlighting your research experience/capabilities and why you wish to undertake a PhD in the team; 

•        Names and addresses of two referees; 

•        Copies of your degree certificates with transcripts written in English; 

•        Evidence of your proficiency in the English language, if applicable. 

•        Evidence of scholarship application/funding or independent funding.

ADDITIONAL INFORMATION

University of Birmingham offers pre-sessional English Language courses through the Birmingham International Academy – https://www.birmingham.ac.uk/international/bia/presessional/index.aspx

For additional information on postgraduate studying at University of Birmingham please click - https://www.birmingham.ac.uk/study/postgraduate

For additional information on research at the College of Medical and Dental Sciences please click – https://www.birmingham.ac.uk/research/activity/mds/index.aspx

For additional information on research in the Institute of Cardiovascular Sciences please click – https://www.birmingham.ac.uk/research/cardiovascular-sciences/index.aspx

Medicine (26)

Funding Notes

Applicants are invited from self-funded or scholarship-funded graduates ONLY
Applicants will be self-funded or will have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.
Overseas graduates require IELTs of 6.5 overall.
Applying directly to the Institute of Cardiovascular Sciences for either a 3 or 4 year full-time PhD – https://www.birmingham.ac.uk/postgraduate/courses/research/med/cardiovascular-sciences.aspx
Applying to the 4 year Integrated Doctoral Training Programme in Life Sciences for Health, which combined a MRes and PhD – https://www.birmingham.ac.uk/postgraduate/pgr/idtp/index.aspx.

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