Disordered multicomponent systems to improve the properties of poorly soluble drugs (Solid state pharmaceuticals)

The project:
From a pharmaceutical perspective, solubility is one of the most critical factors to be considered in formulation design and poorly water soluble drugs pose a challenge to pharmaceutical industries today. Disordered forms of such drugs, ideally suitably stabilised by pharmaceutical excipient(s), are one of the approaches that could be implemented to improve the poor biopharmaceutical properties of active pharmaceutical ingredients. The aim of this project is to manufacture a number of disordered multicomponent systems (DMSs) with optimum biopharmaceutical properties. This project will use a range of processes to generate DMSs and an extensive panel of solid state and biopharmaceutical tools will be used to characterise the relevant properties of the DMSs.

Standard duties and responsibilities:
The PhD student will carry out high quality research as part of the requirements for a PhD at Trinity College Dublin. S(he) will also engage in the structured component of the degree, as required by the university. The student will be involved in training, education and public engagement and any other activities of the Synthesis and Solid State Pharmaceutical Centre (SSPC) as well as is expected to complete an industry/academic placement. In addition, the student will be required to attend regular meetings with the supervisor and the group, attend SSPC meetings, write reports, communicate and disseminate information/research findings at conferences and publish research findings.

Person specifications:

Essential
• At least a 2.1 honors degree in pharmacy, chemistry, pharmaceutical/material sciences, chemical engineering, physics or a related discipline.
• Proficiency in the English language
• An aptitude/strong interest in pharmaceutics research
• Excellent written and communication skills
• Highly motivated
• Ability to work independently and as part of a multidisciplinary team
• Flexibility with regard to the research environment

Desirable
• Previous research experience is desirable.

The successful candidate will be registered for a PhD degree in the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin. The successful PhD candidate will commence March 2020.