About the Project
Acinetobacter baumannii is a Gram negative coccobacillus that is associated with hospital-acquired infections worldwide. It is an opportunistic pathogen that can colonise a range of anatomical sites in immune compromised individuals leading to a variety of life threatening clinical complications. ~2% of all health care associated infections in Europe and USA are caused by this pathogen. The greatest concern associated with this pathogen however is that between 45 - 70% of isolates exhibit multidrug resistance; rates that are significantly higher than those observed for other Gram negative pathogens such as Pseudomonas aeruginosa.
This proposed research project aims to identify compounds and proteins that can disrupt the underlying regulatory mechanisms that allow Acinetobacter baumannii to resist treatment and persist in the hospital environment. We will use a combination of custom designed biosensors, invertebrate model organisms, high through put screening and artificial models of infection persistence to identify potential new antimicrobials. The mechanism of action of these candidates will then be explored using a range of classical microbiology and genetic approaches. To determine specificity, the impact of these new antimicrobials on the native microbiome will also be investigated using next generation sequencing technologies.
Recently the UK Government made available the Doctoral Student Loans of up to £25,000 for UK and EU students and there is some funding available through the Research Councils. Many of our international students benefit from funding provided by their governments or employers. Brunel alumni enjoy tuition fee discounts of 15%.
Based on your current searches we recommend the following search filters.
Based on our current search criteria we thought you might be interested in these.
Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy
University of Nottingham