We are looking for a highly motivated scientist interested in investigating synaptic function and neurotransmitter release; the fundamental roles of a neuron. Control of these functions are complex and still being unraveled. The autolysosomal pathway (ALP) is a critical process in controlled protein degradation in all cells. Intriguingly these two neurobiological functions have been recently linked, with the physiological localized release of Ca2+ by lysosomes modulating synaptic activity via NAADP signaling. Indeed, lysosomes are recruited to dendritic spines upon increased neuronal activity and facilitate synaptic plasticity. This highlights an ability for one function to control the other, however, the causal nature of which controls which, and the temporal aspect of this physiological interaction requires definition. Since both these functions are disrupted in Parkinson’s (PD), understanding the basic physiological interaction of synapse control and ALP is imperative to understanding the dysregulation and impact in PD.
To address this we are looking for a candidate that will map the evolution of both normal synaptic function and the emergence of functional ALP in human induced pluripotent stem cells (iPSC) derived neurons. They will then utilise optogenetics to dissect which of these functions controls the other and how.
The candidate will utilise exciting new technology: high throughput spinning disk confocal microscopy, multi-electrode array and optogenetics specifically working on human neurons derived from iPSC. The candidate will form part of a closely knit team who are working on various aspects of synaptic PD research, but whose work is integrated with one another. As such, the candidate will have mentorship from multiple sources, and must work well both independently and as part of a team. The research environment of the UK Dementia Research Institute at Cardiff University is part of an MRC network and provides significant collaborative opportunities both locally and nationally. The candidate must be willing to learn as well as contribute to the teams scientific and outreach efforts and bring a willingness to develop the project if necessary.
We aspire to train, the brightest and best and believe this is only possible through attracting targets from a range of backgrounds. Thus applications are welcomed and encouraged from all backgrounds.
Entry Requirements
Applicants should possess a minimum of an upper second class Honours degree, master's degree, or equivalent in a relevant subject.
Applicants whose first language is not English are normally expected to meet the minimum University requirements (e.g. 6.5 IELTS).
How to Apply
This studentship has a start date of April 2023. In order to be considered you must submit a formal application via Cardiff University’s online application service.
There is a box at the top right of the page labelled ‘Apply’, please ensure you select the correct ‘Qualification’ (Doctor of Philosophy), the correct ‘Mode of Study’ (Full Time) and the correct ‘Start Date’ (April 2023). This will take you to the application portal.
In order to be considered candidates must submit the following information:
• Supporting statement
• CV
• Qualification certificates
• References x 2
• Proof of English language (if applicable)
International applicants are welcomed if the difference in fees can be covered.
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